Ekkehard Schulze , PhD

Ekkehard Schulze , PhD

Ekkehard Schulze, PhD

Education and Research

I studied biology at the Georg August University in Göttingen. In 1992 I received my PhD degree (Dr.rer.nat. with honors) in the Department of Developmental Biology. For the next two years I worked as a postdoc in the lab of Prof. Grossbach, Developmental Biology, at the Georg August University and until 1995 as a Senior Research Associate at the Institute of Pathology of Prof. Joseph Ilan at the Case Western Reserve University, Cleveland, Ohio. In 1996 I returned to the University of Göttingen, where I worked in the Department of Developmental Biology as a group leader and principal investigator of a C. elegans research group. I received habilitation and a Venia legendi for developmental biology from the Georg August University Göttingen 2003. In 2004 I joined the group of Ralf Baumeister as a Senior Scientist (Akademischer Rat) in Freiburg. My Venia legendi from the Albert-Ludwigs University is for molecular genetics and also for bioinformatics.

Honors and Awards

1985-1988: Scholarship of the German National Scholarship Foundation
1987: Prize of the Lower Saxony Minister of Science and Arts for excellent studental work in science
1989: Member of the 101st Embryology Course Class, Marine Biological Laboratory, Woods Hole, MA. Course Director: Eric H. Davidson
1990-1992: Stipend according to the Lower Saxony law for the support of graduate students
1994-1996: Research Fellowship of the Deutsche Forschungsgemeinschaft: Gene therapy of cancer by IGF-I antisense RNA expression
1998: Participant of the EMBO Practical Course on Molecular, Genetic and Informatic Methods for C. elegans. Course Directors: Alan Coulson and Jonathan Hodgkin
1997-1998: DFG grant SCHU 1033 / 2-1: Artificial repression of transcription by triplex-forming RNAs in stable transfected culture cells
1998-2000: DFG grant RU 725/1-2 (D. Rudoplph, G. Schmahl, E. Schulze):X-ray microscopical analysis of protein and nucleic acid distributions in eukaryotic cells and chromosomes
1998-2004: DFG grant: SCHU 1033 / 1-3: Molecular analysis of the functions of linker histone variants in Caenorhabditis elegans
2000-2002: DFG grant SFB271 Project A14: Molecular analysis of the morphogenesis of the C. elegans dauer larva
2000-2002: Member of the Sonderforschungsbereich (SFB) 271: ‘Molecular genetics of morphoregulatory processes’
2000-2004: Member of international program ‘Masters Molecular Biology’ at the University of Göttingen
2000-2004: Member of DFG Graduiertenkolleg 242 ‘Molecular genetics of Development’ at the University of Göttingen

Memberships in Scientific and professional societies

German National Scholarship Foundation
German Genetics Society

Publications

Targeted purification of SnAvi-tagged proteins.
Schäffer U, Baumeister R, Schulze E.
Methods Mol Biol. 2014;1177:163-74.  PMID: 24943322

Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans.
Weinberg F, Schulze E, Fatouros C, Schmidt E, Baumeister R, Brummer T.
Gene Expr Patterns. 2014 Jul;15(2):124-34. PMID: 24929033

Mitochondrial stress: balancing friend and foe.
Runkel ED, Baumeister R, Schulze E.
Exp Gerontol. 2014 Aug;56:194-201. PMID: 24603155

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response.
Runkel, E., Liu, S., Baumeister, R.* and Schulze E. *corresponding author
PLoS Genet 2013 9(3): e1003346. 
 PMID: 23516373

Temperature- and Touch-Sensitive Neurons Couple CNG and TRPV Channel Activities to Control Heat Avoidance in Caenorhabditis elegans.
Liu S, Schulze E, Baumeister R
PLoS One. 2012;7(3):e32360 PMID: 22448218

Novel roles of C. elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.
Studencka M, Konzer A, Moneron G, Wenzel D, Opitz L, Salinas-Riester G, Bedet C, Krüger M, Hell SW, Wisniewski JR, Schmidt H, Palladino F, Schulze E, Jedrusik-Bode M
Mol Cell Biol. 2011 Nov 14; PMID: 22083954

SnAvi – a new tandem tag for high-affinity protein-complex purification.
Schäffer U, Schlosser A, Müller KM, Schäfer A, Katava N, Baumeister R, Schulze E.
Nucleic Acids Res. 2010 Jan 4. PMID: 20047968

G1 phase-dependent nucleolar accumulation of human histone H1x.
Stoldt S, Wenzel D, Schulze E, Doenecke D, Happel N
Biol Cell. 2007 Oct;99(10):541-52 PMID: 17868027

Linker histone HIS-24 (H1.1) cytoplasmic retention promotes germ line development and influences histone H3 methylation in Caenorhabditis elegans.
Jedrusik MA, Schulze E
Mol Cell Biol. 2007 Mar;27(6):2229-39 PMID: 17210650

Characterisation of human histone H1x.
Happel N, Schulze E, Doenecke D
Biol Chem. 2005 Jun;386(6):541-51 PMID: 16006241

Analysis of germline chromatin silencing by double-stranded RNA-mediated interference (RNAi) in Caenorhabditis elegans.
Jedrusik MA, Schulze E
Methods Mol Biol. 2004;254:35-48 PMID: 15041754

Functional analysis of the single calmodulin gene in the nematode Caenorhabditis elegans by RNA interference and 4-D microscopy.
Karabinos A, Büssing I, Schulze E, Wang J, Weber K, Schnabel R
Eur J Cell Biol. 2003 Nov;82(11):557-63 PMID: 14703012

In vivo and in vitro evidence that the four essential intermediate filament (IF) proteins A1, A2, A3 and B1 of the nematode Caenorhabditis elegans form an obligate heteropolymeric IF system.
Karabinos A, Schulze E, Schünemann J, Parry DA, Weber K
J Mol Biol. 2003 Oct 17;333(2):307-19 PMID: 14529618

The maintenance of neuromuscular function requires UBC-25 in Caenorhabditis elegans.
Schulze E, Altmann ME, Adham IM, Schulze B, Fröde S, Engel W
Biochem Biophys Res Commun. 2003 Jun 6;305(3):691-9 PMID: 12763049

Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing.
Jedrusik MA, Schulze E
Mol Cell Biol. 2003 May;23(10):3681-91 PMID: 12724425

The Caenorhabditis elegans ortholog of human PHF5a shows a muscle-specific expression domain and is essential for C. elegans morphogenetic development.
Trappe R, Schulze E, Rzymski T, Fröde S, Engel W
Biochem Biophys Res Commun. 2002 Oct 4;297(4):1049-57 PMID: 12359262

Expression profiles of the essential intermediate filament (IF) protein A2 and the IF protein C2 in the nematode Caenorhabditis elegans.
Karabinos A, Schulze E, Klisch T, Wang J, Weber K
Mech Dev. 2002 Sep;117(1-2):311-4 PMID: 12204276

A novel linker histone-like protein is associated with cytoplasmic filaments in Caenorhabditis elegans.
Jedrusik MA, Vogt S, Claus P, Schulze E
J Cell Sci. 2002 Jul 15;115(Pt 14):2881-91 PMID: 12082149

A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans.
Jedrusik MA, Schulze E
Development. 2001 Apr;128(7):1069-80 PMID: 11245572

The histone H1 genes of the dipteran insect, Chironomus thummi, fall under two divergent classes and encode proteins with distinct intranuclear distribution and potentially different functions.
Trieschmann L, Schulze E, Schulze B, Grossbach U
Eur J Biochem. 1997 Nov 15;250(1):184-96 PMID: 9432008

The expression of the imprinted genes H19 and IGF-2 in choriocarcinoma cell lines. Is H19 a tumor suppressor gene?
Lustig-Yariv O, Schulze E, Komitowski D, Erdmann V, Schneider T, de Groot N, Hochberg A
Oncogene. 1997 Jul 10;15(2):169-77 PMID: 9244352

Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells.
Rininsland F, Johnson TR, Chernicky CL, Schulze E, Burfeind P, Ilan J
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5854-9 PMID: 9159164

The Vertebrate Linker Histones H10, H5, and H1M Are Descendants of Invertebrate “Orphon” Histone H1 Genes
Schulze E, Schulze B
J Mol Evol. 1997 Apr;44(4):466-7 PMID: 9089088

Potential triple helix-mediated inhibition of IGF-I gene expression significantly reduces tumorigenicity of glioblastoma in an animal model.
Shevelev A, Burfeind P, Schulze E, Rininsland F, Johnson TR, Trojan J, Chernicky CL, Hélène C, Ilan J, Ilan J
Cancer Gene Ther. 1997 Mar-Apr;4(2):105-12 PMID: 9080119

Developmentally imprinted genes as markers for bladder tumor progression.
Cooper MJ, Fischer M, Komitowski D, Shevelev A, Schulze E, Ariel I, Tykocinski ML, Miron S, Ilan J, de Groot N, Hochberg A
J Urol. 1996 Jun;155(6):2120-7 PMID: 8618347

The vertebrate linker histones H1 zero, H5, and H1M are descendants of invertebrate “orphon” histone H1 genes.
Schulze E, Schulze B
J Mol Evol. 1995 Dec;41(6):833-40 PMID: 8587127

The expression of the imprinted H19 and IGF-2 genes in human bladder carcinoma.
Elkin M, Shevelev A, Schulze E, Tykocinsky M, Cooper M, Ariel I, Pode D, Kopf E, de Groot N, Hochberg A
FEBS Lett. 1995 Oct 23;374(1):57-61 PMID: 7589512

Insect proteins homologous to mammalian high mobility group proteins I/Y (HMG I/Y). Characterization and binding to linear and four-way junction DNA.
Claus P, Schulze E, Wiśniewski JR
J Biol Chem. 1994 Dec 30;269(52):33042-8 PMID: 7806532

Structurally divergent histone H1 variants in chromosomes containing highly condensed interphase chromatin.
Schulze E, Nagel S, Gavenis K, Grossbach U
J Cell Biol. 1994 Dec;127(6 Pt 2):1789-98 PMID: 7806560

DNA binding and nuclear translocation of insect high-mobility-group- protein-1 (HMG1) proteins are inhibited by phosphorylation.
Wiśniewski JR, Schulze E, Sapetto B
Eur J Biochem. 1994 Oct 15;225(2):687-93 PMID: 7957184

High affinity interaction of dipteran high mobility group (HMG) proteins 1 with DNA is modulated by COOH-terminal regions flanking the HMG box domain.
Wiśniewski JR, Schulze E
J Biol Chem. 1994 Apr 8;269(14):10713-9 PMID: 8144661

Structural and functional differences between histone H1 sequence variants with differential intranuclear distribution.
Schulze E, Trieschmann L, Schulze B, Schmidt ER, Pitzel S, Zechel K, Grossbach U
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2481-5 PMID: 8460162

Insect proteins homologous to mammalian high mobility group protein 1. Characterization and DNA-binding properties.
Wiśniewski JR, Schulze E
J Biol Chem. 1992 Aug 25;267(24):17170-7 PMID: 1512255

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