The Baumeister Laboratory
https://www.cibss.uni-freiburg.de/about/home/ is part of the Institute for Biology 3 of the Albert-Ludwig University in Freiburg/Breisgau, Germany.
Ralf Baumeister is member of:
Faculty of Biology
Faculty of Medicine
BIOSS Cluster of Excellence (Centre of Biological Signalling Studies)
CIBSS Cluster of Excellence (Centre for Integrative Biological Signaling Studies)
SGBM (Spemann Graduate School of Biology and Medicine)
IMBS (International Master in Medical and Biological Sciences, Univ. of Freiburg and Buenos Aires, Argentina
He is also member of the scientific network of NCL (the private foundation National Contest for Life (NCL) to fight hereditary neurodegenerative diseases of childhood).
The lab and its members contribute to teaching in
Biology (B.Sc. and M.Sc. modules)
Biology for Medical Students
Biology for Students of Dental Medicine
International Master program in Medical and Biological Sciences
Info on the teaching program of the Faculty of Biology can be found here
Our lab focuses on the functional analysis of genes involved in aging and age-related diseases. To combine the characterization of gene function and the dissection of entire genetic pathways with a biochemical understanding of the proteins, our models include the nematode Caenorhabditis elegans (C. elegans) and human cell culture. In addition, we use yeast models to answer specific questions whenever it is advantageous. Biochemical analyses and pharmacological assays to test chemical interference with protein function are performed to understand, in addition to the genetic details, the precise role of a protein and its physical interactions in a living organism.
So far, all of the mechanisms that we have identified using C. elegans models have been shown to be remarkably similar in the mammalian organism, and have helped a lot to understand the biological function of the human gene that is dysfunctional in disease.
We currently focus on genes involved in insulin/IGF and mTOR signaling, as well as genes implicated in Parkinson’s Disease, intracellular dynamics, and the cellular and intracellular/mitochondrial responses to nutrient and stress.
The lab is currently funded by
The German Research Council (DFG Deutsche Forschungsgemeinschaft)
SFB 746 Functional Specificity by coupling and modification of proteins
SFB 850 Control of cell motility in morphogenesis, tumor invasion and metastasis
BIOSS – Centre for Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg
CIBSS – Centre for Integrative Biological Signaling Studies, Albert-Ludwigs-Universität Freiburg
BMBF (Federal Ministry of Education and Research), (NGFN) National Network for Genome Research
Collaborations with the Pharmaceutical Industry
GRAKO 1104 From cells to organs: Molecular mechanisms of Organogenesis
SGBM Spemann Graduate School of Biology and Medicine
IMBS International Master in Medical and Biological Sciences
IRTG Integrated Research Training Group of CRC850